Ibuprofen Side Effects
Brand Names: Advil, IBU, NeoProfen, Motrin
Please note - some side effects for Ibuprofen may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).
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For the consumer
For the professional
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Side Effects of Ibuprofen - for the consumer
Ibuprofen/Oxycodone
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Ibuprofen/Oxycodone:
Seek medical attention right away if any of these SEVERE side effects occur when using Ibuprofen/Oxycodone:Anxiety; constipation; diarrhea; dizziness; drowsiness; headache; indigestion; infection; nausea; nervousness; sleeplessness; stomach pain; swelling; tiredness; upset stomach; vomiting; weakness.
Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry, or bloody stools; blurred vision or other eye problems; chest pain; dark urine; fainting; fast or irregular heartbeat; fever; increased or decreased urination; irregular or difficult breathing; mental or mood changes; red, swollen, blistered, or peeling skin; severe or persistent dizziness; severe or persistent stomach pain; stiff neck; swelling of the arms or legs; unusual tiredness or weakness; unusual weight gain; vomit that looks like coffee grounds; yellowing of the skin or eyes.
Ibuprofen
All medicines can cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Ibuprofen:
Seek medical attention right away if any of these SEVERE side effects occur when using Ibuprofen:Constipation; diarrhea; dizziness; gas; headache; heartburn; nausea; stomach pain or upset.
Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; stiff neck; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.
Ibuprofen Capsules
All medicines can cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Ibuprofen Capsules:
Seek medical attention right away if any of these SEVERE side effects occur when using Ibuprofen Capsules:Constipation; diarrhea; dizziness; gas; headache; heartburn; nausea; stomach pain or upset.
Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; stiff neck; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.
Ibuprofen Chewable Tablets
All medicines can cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Ibuprofen Chewable Tablets:
Seek medical attention right away if any of these SEVERE side effects occur when using Ibuprofen Chewable Tablets:Constipation; diarrhea; dizziness; gas; headache; heartburn; nausea; stomach pain or upset.
Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; stiff neck; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.
Ibuprofen Drops
All medicines can cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Ibuprofen Drops:
Seek medical attention right away if any of these SEVERE side effects occur when using Ibuprofen Drops:Constipation; diarrhea; dizziness; gas; headache; heartburn; nausea; stomach pain or upset.
Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; stiff neck; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.
Ibuprofen Suspension
All medicines can cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Ibuprofen Suspension:
Seek medical attention right away if any of these SEVERE side effects occur when using Ibuprofen Suspension:Constipation; diarrhea; dizziness; gas; headache; heartburn; nausea; stomach pain or upset.
TopSevere allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; stiff neck; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.
For the professional
Ibuprofen
The most frequent type of adverse reaction occuring with Ibuprofen tablets is gastrointestinal. In controlled clinical trials the percentage of patients reporting one or more gastrointestinal complaints ranged from 4% to 16%.
In controlled studies when Ibuprofen tablets were compared to aspirin and indomethacin in equally effective doses, the overall incidence of gastrointestinal complaints was about half that seen in either the aspirin- or indomethacin-treated patients.
Adverse reactions observed during controlled clinical trials at an incidence greater than 1% are listed in the table. Those reactions listed in Column one encompass observations in approximately 3,000 patients. More than 500 of these patients were treated for periods of at least 54 weeks.
Still other reactions occurring less frequently than 1 in 100 were reported in controlled clinical trials and from marketing experience. These reactions have been divided into two categories: Column two of the table lists reactions with therapy with Ibuprofen tablets where the probability of a causal relationship exists: for the reactions in Column three, a causal relationship with Ibuprofen tablets has not been established.
Reported side effects were higher at doses of 3200 mg/day than at doses of 2400 mg or less per day in clinical trials of patients with rheumatoid arthritis. The increases in incidence were slight and still within the ranges reported in the table.
| Incidence Greater than 1% (but less than 3%) Probable Causal Relationship |
Precise Incidence Unknown (but less than 1%) Probable Causal Relationship* |
Precise Incidence Unknown (but less than 1%) Causal Relationship Unknown* |
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GASTROINTESTINAL Nausea†, epigastric pain†, heartburn†, diarrhea, abdominal distress, nausea and vomiting, indigestion, constipation, abdominal cramps or pain, fullness of GI tract (bloating and flatulence). |
Gastic or duodenal ulcer with bleeding and/or perforation, gastrointestinal hemorrhage, melena, gastritis, hepatitis, jaundice, abnormal liver function tests; pancreatitis. |
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CENTRAL NERVOUS SYSTEM Dizziness†, headache, nervousness |
Depression, insomina, confusion, emotional lability, somnolence, aseptic meningitis with fever and coma |
Paresthesias, hallucinations, dream abnormalities, pseudotumor cerebri |
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DERMATOLOGIC Rash† (including maculopapular type), pruritus |
Vesiculobullous eruptions, urticaria, erythema multiforme, Stevens-Johnson syndrome, alopecia. |
Toxic epidermal necrolysis, photoallerigc skin reactions |
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SPECIAL SENSES Tinnitus |
Hearing loss, amblyopia (blurred and/or diminished vision, scotomata and/or changes in color vision) |
Conjunctivitis, diplopia, optic neuritis, cataracts |
| HEMATOLOGIC |
Neutropenia, agranulocytosis, aplastic anemia, hemolytic anemia (sometimes Coombs Positive), thrombocytopenia with or without purpura, eosinophilia, decreases in hemoglobin and hematocrit |
Bleeding episodes (eg epistaxis, menorrhagia) |
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METABOLIC/ENDOCRINE Decreased appetite |
Gynecomastia, hypoglycemic reaction, acidosis |
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CARDIOVASCULAR Edema, fluid retention (generally responds promptly to drug discontinuation) |
Congestive heart failure in patients with marginal cardiac function, elevated blood pressure, palpitations |
Arrhythmias (sinustachycardia, sinus bradycardia) |
| ALLERGIC |
Syndrome of abdominal pain, fever, chills, nausea and vomiting; anaphylaxis; bronchospasm |
Serum sickness, lupus erythematosus syndrome. Henoch-Schonlein vasculitis, angioedema |
| RENAL |
Acute renal failure, decreased creatinine clearance, polyuria, azotemia, cystitis, hematuria. |
Renal papillary necrosis |
| MISCELLANEOUS |
Dry eyes and mouth, gingival ulcer, rhinitis |
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More resources:
Ibuprofen - Includes detailed dosage instructions.
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